Mechanobiology of cytokinesis. How do cells physically divide?
Selected Publications
Chambaud, G. D., Martin, V. C. and Hickson, G. R. (2025). Anillin links up with RhoA to break the symmetry of cytokinetic ring closure. Spotlight Article, J. Cell Biol. Jun 2;224(6):e202504164.
doi: 10.1083/jcb.202504164. https://rupress.org/jcb/article-lookup/doi/10.1083/jcb.202504164
Carim, S.C. & Hickson, G. R. (2023). The Rho1 GTPase controls anillo-septin assembly to facilitate contractile ring closure during cytokinesis. iScience. 26(6): 106903. https://doi.org/10.1016/j.isci.2023.106903
Hickson, G. R. (2022). A back-up source of microtubules for the midbody during cytokinesis. Spotlight Article, J. Cell Biol. 221: e202201028. doi: 10.1083/jcb.202201028. https://rupress.org/jcb/article/221/3/e202201028/213023
Carim, S.*, Kechad, A.* & Hickson, GRX. (2020) Hypothesis and Theory: The Rho-dependent actomyosin-anilloseptin contractile ring as a membrane microdomain gathering, compressing and sorting machine. Front Cell Dev Biol 8:575226. doi: 10.3389/fcell.2020.575226. https://www.frontiersin.org/articles/10.3389/fcell.2020.575226/full
El-Amine, N.*, Carim, S.*, Wernike, D*. & Hickson, GRX. (2019) Rho-dependent control of the Citron kinase, Sticky, drives midbody ring maturation.Mol. Biol. Cell 30(17): 2185-2204. doi: 10.1091/mbc.E19-04-0194 https://www.molbiolcell.org/doi/10.1091/mbc.E19-04-0194
Carim, S.C., El Kadhi, K.B., Yan., G., Sweeney, S.T., Hickson, G.R., Carréno, S. and Lowe, M. (2019) IPIP27 coordinates PtdIns (4,5) P2 homeostasis for successful cytokinesis. Curr. Biol. 29(5) 775-789. https://doi.org/10.1016/j.cub.2019.01.043
Jananji, S., Risi, C., Lindamulage, I.K., Picard, L-P, Van Sciver, R., Laflamme, G., Albaghjati, A., Hickson, G.R*, Kwok., B. H.*, and Galkin, V.E.* Multimodal and polymorphic interactions between anillin and actin: their implications for cytokinesis. J. Mol. Biol. 2017. pii: S0022-2836(17)30061-X. doi: 10.1016/j.jmb.2017.01.020 * co-corresponding authors http://www.sciencedirect.com/science/article/pii/S002228361730061X
Kechad, A & Hickson, G. R. (2017). Imaging cytokinesis of Drosophila S2 cells. Methods Cell Biol. 2017;137:47-72. doi: 10.1016/bs.mcb.2016.03.034 http://www.sciencedirect.com/science/article/pii/S0091679X1630026
El Amine, N., Kechad, A, Janani, S. & Hickson, G. R. (2013). Opposing actions of septins and Sticky on Anillin promote the transition from contractile to midbody ring. J Cell Biol. 2013 Nov 11;203(3):487-504. doi: 10.1083/jcb.201305053 https://rupress.org/jcb/doi/10.1083/jcb.201305053
Kechad, A., Jananji, S., Ruella, Y. & Hickson, G. R. (2012). Anillin acts as a bifunctional linker coordinating midbody ring biogenesis during cytokinesis. Curr Biol. 2012 Feb 7;22(3):197-203. doi: 10.1016/j.cub.2011.11.062.
https://www.sciencedirect.com/science/article/pii/S0960982211013959
Hickson, G. R. & O'Farrell, P. (2008). Rho-dependent control of anillin behavior during cytokinesis. J Cell Biol. 2008 Jan 28;180(2):285-94.doi: 10.1083/jcb.200709005.